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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing -- atom by atom -- both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS.

You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

• Sales Rank: #132962 in eBooks
• Published on: 2013-08-20
• Released on: 2013-08-20
• Format: Kindle eBook

Amazon.com Review
From test tubes to the Wall Street IPO and beyond, this is the riveting true story of a start-up pharmaceutical company working to create an anti-AIDS drug. Scientifically accurate, yet written with an attention to plot, timing, dialogue, and development of character more characteristic of the best thrillers.

From Publishers Weekly
A startup pharmaceutical company is the focus of this intriguing look at the nexus of biotechnology and high finance; features a new epilogue by the author.
Copyright 1995 Reed Business Information, Inc.

From Library Journal
Werth, a freelance writer on science and business issues, chronicles Joshua Boger's start-up of Vertex, a biotechnology company dedicated to the discovery of new drugs. Boger, a successful organic chemist with Merck, left his position as a senior director to establish Vertex. He recruited an exceptional group of researchers with the aim of integrating the most advanced disciplines in molecular biology to develop an immune-suppressing drug used in organ transplants and a potent HIV protease inhibitor to help thwart AIDS. Werth also discusses Vertex's financing and initial public stock offering. Recommended for science and business collections in public libraries and for special libraries in the pharmaceutical industry.
- Bruce Slutsky, New Jersey Inst. of Tech. Lib., Newark
Copyright 1994 Reed Business Information, Inc.

Most helpful customer reviews

35 of 37 people found the following review helpful.
difficult, fascinating, and compelling birth of a company
By Robert J. Crawford
This is the story of the first few years of Vertex, a bioventure that sought to create drugs that were constructed molecule by molecule - it is supposed to be "rational drug design". In exchange for allowing the company to check his work for accuracy and proprietary disclosures, Werth was admitted into the inner circle of the company, with both executives and scientists, for four years.

Werth offers masterful descriptions of both the science and the intricacies of the busisess deals. The work is similar to that of Tracy Kidder in "The Soul of a New Machine" and, in my opinion, of the same quality.

At the center of the story is Vertex's founding visionary, Joshua Boger, formerly a researcher at Merck. He reasoned that instead of screening soil samples and insect secretions in a hot or miss approach in thousands of petri dishes, he could design drugs atom by atom to bind to - and thus inactivate - molecules instrumental to the disease process. In theory, these drugs would be without side effects: because of the precision of the design, they would adhere to their target alone, allowing beneficial enzymes of other chem reactions to go on unimpeded.

Boger's first target molecule was FKBP, which he believed was a crucial agent of the immune system. By blocking it, he hoped to prevent the host's body from rejecting transplanted organs. While Boger was out raising money (eventually reaching $60 million), Vertex's researchers hunkered down to isolate and analyze FKBP, whose molecular mechanic remained poorly understood.

Unfortunately, what happened is a great example of the difficulties in marrying business to cutting-edge science: after over two years of pushing themselves to the brink of nervous collapse, Vertex scientists found difficulties with FKBP. Even worse, Boger's arch rival, a prof at Harvard, discovered why. The prof beat VErtex, Werth argues, because he remained outside the venture capital game and could thus concentrate totally on the science and could openly collaborate with them rather than hide proprietary results.

Nonetheless, driven and confident as ever, Boger turned his scientific team onto the new problem. Thru all of this, Boger comes off as a fascinating character: the son of a suicide, he is unshakably convinced that he can bend nature as well as the business world to his will. The reader sees what lies behind the herculean efforts of him and his team.

Warmly recommended as a rivetting tale of human endeavor that embraces the true complexity.

14 of 15 people found the following review helpful.
Fast-paced and Insightful
By EarlRandy
I first read this book nearly two years ago as research for a novel I was writing. Recently, I turned to it once more to pick up a few terms and found myself reading chapter after chapter!
This non-fiction tale has enough twists and turns and drama to match any thriller on the market. An informative and engaging tale of a pharmaceutical start-up and the people involved. Joshua is interesting enough that the book could have been solely about him, but he isn't the only one. All of the players in this ego-driven mega-drama are interesting on many levels.
Who would I reccomend this book to? Anyone who likes a well-told story. A background in medicine is not needed, and neither is a knowledge of business practices. All you need to enjoy this book is a brain . . . and a night light because you'll be reading this book deep into the night.

5 of 5 people found the following review helpful.
The Billion Dollar Molecule - One Company's Quest...
By thesheerans
A thouroughly enjoyable read, Werth sheds light on the personaliteis and complexities of an amazing and multifaceted business. Throughout, the author uncovers the unseen deal-making, hand-wringing, and fist clenching that dominate the start of Vertex, a strucure-based paharmaceutical firm.
I particularly enjoyed the background on the Boger-Schreiber collaboration and rivalry, and the ensuing rivalry in Vertex's own labs. Further, following the last few years of Vertex's ups and downs via the Internet has been thoroughly enjoyable.
Werth's style is easliy read, and his obvious unhindered access to Vertex and its people make the story enjoyable, suspenseful, and dramatic.

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• Sales Rank: #117375 in Books
• Brand: Project Management Institute (COR)
• Published on: 2015-01-01
• Original language: English
• Number of items: 1
• Dimensions: 10.70" h x .60" w x 8.30" l, .0 pounds
• Binding: Paperback
• 206 pages

Most helpful customer reviews

2 of 2 people found the following review helpful.
Great book full of practical tips and tricks for the ...
By pebbles
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0 of 0 people found the following review helpful.
Five Stars
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Five Stars
By Omaha Willie
Great for the BA.

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Horses allow ordinary people to do extraordinary things, and this extraordinary book shows you how.

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• Sales Rank: #374278 in Books
• Published on: 2012-03-05
• Released on: 2012-03-05
• Original language: English
• Number of items: 1
• Dimensions: 9.60" h x 1.30" w x 8.00" l, 3.10 pounds
• Binding: Hardcover
• 400 pages

About the Author
William Micklem has been a national coach for the Irish Horse Board and trainer director at Gleneagles' Mark Phillips Equestrian Center. In addition to being a television commentator and contributor to equestrian journals, he has also discovered several top-quality horses, including Bico, Custom Made, and Gilt Edge.

Most helpful customer reviews

5 of 5 people found the following review helpful.
Excellent English Riding and Dressage Reference
By jsr
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This book is intended as an accompaniment for a student actively taking lessons.

What is not covered in here is Western style riding, steeplechase, horse racing, grooming, and polo. I would like to see a book like this covering those subjects though! I was considering buying other books to add to my equestrian library, but my instructor and I find this one to be extremely complete and accurate.

I take lessons with the people that wrote this book, Getting the Most from Riding Lessons (Horse Wise Guides). I suggest looking into this book as well.

3 of 3 people found the following review helpful.
daughter loves this book
By mom
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2 of 2 people found the following review helpful.
Do Not Miss!
By Pat
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The stories behind more than 50 secret projects undertaken by the famed Lockheed Martin Skunk Works on behalf of the US Armed Forces, DARPA, and the CIA - all illustrated with official Skunk Works photography and commissioned artworks.

Hatched in June 1943 after a special request of the US Army Air Forces to develop a turbojet-powered fighter to counter growing German threats, Lockheed Martin's Skunk Works has gone on to develop remarkable aeronautical and space technologies, including stealth. Some have made it into production, while others never quite made it off drafting boards and computer screens, but proved fascinating nonetheless.

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• Sales Rank: #139739 in Books
• Published on: 2016-12-01
• Original language: English
• Dimensions: 11.10" h x 1.02" w x 9.49" l, .0 pounds
• Binding: Hardcover
• 256 pages

About the Author

Steve Pace is a freelance aviation history writer, a contributing editor to Flight Journal, and the author of numerous articles and short features on a variety of aircraft and related subjects, as well as thirty aviation history books, including The Big Book of X-Bombers and X-Fighters (2016). He was raised in Seattle, Washington, where his father worked at the Boeing Airplane Company for more than thirty years. As the son of an aircraft builder, he became interested in aviation at an early age - instead of buying candy and marbles, he bought model airplane kits. Pace now resides in Tacoma, Washington.

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• Sales Rank: #5184824 in Books
• Binding: Hardcover

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[D107.Ebook] PDF Ebook Wolf from the Past (Salvation Pack), by N.J. Walters

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Playing dead is easy. Living is hard.

Salvation Pack, Book 4

Sylvie LaForge Dubois knew coming back from the dead wouldn’t be easy, but facing her brother and his friends is harder than she imagined. The way Gator Rollins watches her every move makes her decidedly uneasy and excited.

After surviving a forced mating to the abusive Andre Dubois, having a rugged, dangerous werewolf like Gator sniffing around her is scary and thrilling at the same time. She never imagined she’d want another man, but her bone-deep attraction to Gator is too strong to fight.

Gator never got a chance to tell Sylvie he loved her before she was mated with another and, well, died. Now that she’s back, there’s nothing he won’t do to protect her.

Once word gets out, Sylvie’s former pack will be coming for her. No one leaves the Louisiana pack, especially not a female werewolf. But Gator’s determined that this time he won’t let anyone or anything get between him and Sylvie, even if she can’t decide if his touch makes her want to jump his bones…or run for the hills.

Warning: If you believe in second chances, this story will rock your soul, make you swoon, and bring tears to your eyes. Don’t say we didn’t warn you.

• Sales Rank: #286782 in eBooks
• Published on: 2015-10-13
• Released on: 2015-10-13
• Format: Kindle eBook

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0 of 0 people found the following review helpful.
Wolf from the Past
By Evampire
Sylvie LaForge knew coming back from the dead wouldn’t be easy but the way Gator Rollins watches her every move makes her decidedly uneasy and excited in this gripping paranormal romance.

Gator never got a chance to tell Sylvie that he loved her and now that he has a second chance he’s determined that this time he won’t let anyone or anything get between him and Sylvie and the reader’s heart can’t help but be touched by the love and tenderness that Gator shows Sylvie as she tries to adjust to being among family again. The chemistry between Gator and Sylvie sizzles with lots of heat and the sex scenes are sweet and sensual but with such a horrific past, there is a lot of emotional walls that will need to come down in order for the relationship to progress and these strong, compelling characters grab the attention as the fast paced, smooth flowing plot captivates readers with suspense, excitement, turmoil and romance.

Expectation builds throughout the story as the Salvation Pack realizes that their former pack will be coming for Sylvie and excitement builds as tension within the pack escalates and they discover that someone with an obsession for Sylvie may just be leading the charge. The intriguing events draw the reader in while the well written scenes and details capture the imagination and make it easy for the reader to become absorbed in the story and the intense emotions that flow from every page.

I was thoroughly enthralled by Sylvie and Gator’s story from the very beginning and I have to say that I enjoyed meeting the Salvation Pack but in regards to that while it wasn’t absolutely necessary to read the previous books in the series, I do wish that I had because I missed out on the events that led up to this point but of course that means that I have some enjoyable stories to get busy reading.

1 of 1 people found the following review helpful.
Good read!
By Jacque
Wolf from the Past by N.J. Walters is a double first for me. Both a first by this author and first in the series for me. Sometimes jumping into a series can be a big mistake especially if there is quite a bit of world building to go along with introducing characters. Thankfully, I was able to get right into the story with only a few minor hiccups,

To escape a violent mating, Sylvie has been faking her death for years. Once she receives word her mate was dead, she approaches her brother in his new pack in hopes to have him back in her life. Not only is she welcome back with open arms, but a werewolf she has always had feeling for is part of his pack. Gator was raise in the swamp, always on the fridge of his former Louisiana pack, he has struck out with his friends to form a new pack. He's always wanted his best friend's sister but her parents have never considered him worthy. Now that she's back in his new pack and in his life Gator will do whatever it takes to protect her from further harm.

Wolf from the Past was a good read. Sylvie was abused fairly harshly by her previous mate and as the story about how she faked her death came into play, it was hard not to feel bad for her. Gator is pretty sexy and intense about his feeling for Sylvie. There's a really instant attraction between them that, at first, was kind of difficult to get over. Let's face it, she was abused pretty badly by her dead mate. For her to jump into a relationship so quickly with Gator had me doubting the velocity of the romance. Once, it can out that both had been carrying torches for one another for a long time, then I was okay with it.

What really had me cheering this story on was the dynamics of the Salvation Pack. The interactions of all the mated couples and how they interacted with each other, good stuff here. It was such fun and friendly, it makes me want to go back and read all their stories. On top of that, there is a good world building here with the what and whys of the Salvation Pack. As I mentioned, this is the first book I read in the series, but it's easy to see there's a epic battle coming. There's one more member in the pack that has yet to settle down which tells me I have some back reading to do before the final book comes out.

I received this book from the JeepDiva for the express purposes of an honest review. The opinions and rating of this review are solely mine and in no way was I compensated.
Stars – 3.5, Flames - 3

0 of 0 people found the following review helpful.
I am absolutely in love with the Salvation Pack and its members
By Kim Muhl
As the fourth book in the author’s Salvation Pack series, all I keep asking myself is –

Why have I not read the rest of this series?

And

Why haven’t I read anything from this author before?

N.J. Walters knocks it out of the park with this story, which makes me want to read everything from her! The story is well developed, characters well written, and sexy time is HOT HOT HOT! I am absolutely in love with the Salvation Pack and its members!!

Wolf from the Past features Gator and Sylvie. Coming from an abusive past, Sylvie went on the run and into hiding for a long time. After hearing of her abusive mate’s death, she comes out of hiding and is pleasantly surprised to find that her brother, and a few others, have left her uncle’s tyrannical pack. Her brother, Armand, is relieved to find out that she is alive and ok. But, so is someone else. Gator.

Gator mourned the loss of Sylvie long ago, but now that she is back he wants to claim her as his mate. He loved her long before she left, but circumstances got in the way and they couldn’t together. Understandably, Sylvie is leery about mating to someone else after all she has been through, so Gator must prove his love and loyalty to the broken wolf.

The way Gator went about winning over Sylvie’s trust made me swoon! What a sweet and sexy wolf he is! He didn’t push or intimidate her and instead knew how broken she was and became tender and sweet…exactly what she needed. While their sex scenes were steamy, they were, also, tender and sweet. Again, very swoon worthy! Really, there isn’t anything to not like about this story.

I highly, highly, recommend reading this book and will be stalking….I mean, following….this author from now on!

*Copy was provided for review.

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